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Hindustan Antibiotics Limited (A Govt. of India Enterprise)
Pimpri , Pune - 411018
Under the Ministry of Chemicals and Fertilizers
CIN No. U24231MH1954PLC009265

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Manufacturing Facility

MANUFACTURING  FACILITIES & PRODUCT  PROFILE

1). BULK  DRUG  PLANT  FACILITIES

Hindustan Antibiotics Ltd(HAL) is having infrastructure for manufacture of  fermentation based products which includes  19 x 92 M3 fermentors alongwith its downstream processing, solvent recovery and associated utilities like steam, chilled water, cooling tower water, compressed air etc. These facilities were earlier used for manufacturing fermentation based bulk drugs such as  Penicillin-G and Streptomycin Sulphate. These units are   idle at present and is available for leasing.

2). FORMULATION PLANT FACILITIES

2.1) HAL is having facility for  manufacturing of various Pharma formulation products . HAL’s Pharma products includes various dosage forms of  Betalactum powder Injectable products, Cephalosporin powder Injectable products, Betalactum Tablets & Capsules, Non-Penicillin Tablets, Intra-Venous products, Liquid Syrup etc. HAL has installed state-of-the-art facility for manufacturing Betalactum and Cephalosporin Powder injectables. Cephalosporin powder injectable facility was accredited  with WHO-GMP certification in 2010.  IV Fluid plant is set up with Blow-Fill-Seal technology with machines of Rommleg, Switzerland and has now been upgraded to meet WHO-GMP standards. All the Pharma Formulation plants of HAL are complying to the requirements of Good Manufacturing Practices and Schedule M applicable to Pharma production. Present manufacturing formulation capacities are as follows:-

SR.No. Production facilities Capacities

(Lacs Nos. / annum

A Powder Injectables
i) Cephalosporin Powder Injectable 450
ii) Betalactum Powder Injectable 450
B Tablets
i) Betalactum Tablets 1200
ii) Non-Penicillin Tablets 2400
C Capsules
i) Betalactum capsules 2500
D I.V.Fluids 120
E Liquid Syrup & External preparation 24

2.2). PRODUCT PROFILE

i). Cephalosporin  Powder Injectables (In Various Doses)

* HALTAX (Cefotaxime)
* HAXONE ( Ceftriaxone)
* TRANSUF (Cefaperazone)
* UROX (Cefuroxime sodium)
* HALTAX S ( Cefotaxime Sodium + Sulbactam)
* HAXONE S ( Ceftriaxone Sodium + Sulbactam)
* TRANSUF S ( Cefoperazone Sodium + Sulbactam)

ii). Betalactum  Powder Injectables (In Various Doses)

* DYNACIL (Ampicillin Sodium
* SODICILLIN (Sodium Penicillin)
* LONGACILLIN (Benzathine Penicillin)
* FORTIFIED PROCAINE PENICILLIN

* HALPEN (Meropenum)

iii).Large Volume Parenterals ( Intra Venous Fluids products)

* DEXTROSE
* SODIUM CHLORIDE
* DEXTROSE + SODIUM CHLORIDE
* RINGER LACTATE
* MANNITOL
* METRONIDAZOLE
* CIPROFLOXACIN LACTATE

* PLASMA VOLUME EXPANDER (Polygeline)
* PLAZILOC ( Levofloxacin)

iv). Plain Tablets (Human & Veterinary)

* KAYPEN (PEN. V)
* DELAMIN P & DELAMIN DT(AMOXYCILLIN)
* PRILOCEF-P (CEPHALEXIN)
* CO-TRIMOXAZOLE
* PARACETAMOL
* HALNAZ ( Fluconazole)

v). Coated Tablets (In Different Strengths))

* NORFLOXACIN
* CIPROFLOXACIN
* ERYTHROMYCIN
* DICLOFENAC SODIUM
* RANITIDINE
* DICLOFENAC SODIUM + PARACETAMOL
* PENQUIN TZ (CIPROFLOXACIN + TINIDAZOLE)
* HAXIME (Cefixime)

vi). Sustained Release Tablets (In Different Strengths)

* HALORAN (DICLOFENAC SODIUM)
* Cefixime

vii). Capsules (In Different Strengths)

* PRILOCEF (CEPHALEXIN)
* DELAMIN (AMOXICILLIN)
* AMPICILLIN TRIHYDRATE

viii). Liquid Syrups/Suspensions

* HAMYCIN
* ALBENDAZOLE
* PIPERAZINE

3). AGRO PRODUCTS  MANUFACTURING  FACILITIES

3.1) HAL is also having facility for  manufacturing of various Agro  products . HAL’s Agro products includes Streptocycline, Aureofungin, Humaur, Azotomeal, Phosphomeal etc. Present manufacturing capacities are as follows:-

 

SR.No.

Production facilities  

Capacities

i) Streptocycline (6gm Pouches) 180 Lacs / annum
ii) Aureofungin Bulk 810 kgs/annum*
iii) Humaur formulation 210 KL/annum*
iv) Azotomeal 50 KL/annum*
v) Phosphomeal 50 KL/annum*

*Capacity of these products can be increased depending upon requirement since HAL is having sizable idle fermentation facilities

3.2). Details of Agro- products

i). Streptocycline

Streptocycline is an Antibacterial Antibiotic formulation recommended for effective control of bacterial disease of plant. It is a yellow coloured free flowing powder containing Streptomycin sulphate and Tetracycline Hydro chloride. It is readily soluble in water and being systematic in action gets readily absorbed in the plant when sprayed and does not get washed off in rain.

Streptocycline is very effective for controlling the crop diseases and is available in 6gms in pouch and 500 gms pack. Shelf life of Streptocycline is 24 months

Some of the applications are cited below:-

CROP Disease
Cotton Seedling blight / leaf spot
Grapes Bacterial leaf spot
Pomegranate Bacterial Blight
Rice Bacterial leaf spot
Banana Leaf spot / Leaf blight / Heart rot

ii). Aureofungin

Aureofungin is antifungal antibiotics invented and developed by HAL exclusively for agriculture use. Aureofungin being broad spectrum antibiotic has proved very effective in prevention and control of various fungal diseases. Aureofungin is very effective for controlling the crop diseases. Aureofumgin is bio degradable and does not leave any residue after few days of application. The shelf life of Aureofungin is 24 months.
and is  available 13 gms pouch and 65 gms tin.Aureofungin foliar spray is used for  elimination of seed borne infection, for  better germination and control of disease during storage and transport.  Some of the applications are cited below:-

CROP Disease
Apple Powdery mildew
Banana Anthracnose
Grapes Downy mildew
Wheat Rust
Coconut Wilt
Sugar-cane Red rot and smut

iii). Humaur

Humaur is a by-product of Aureofungin . Humaur is liquid bio, foliar spray for plants. It is nutritionally balanced food for plants. Humaur provides various plant nutrition to crops and increases yield by 20-25%. Humaur is used to enhance germination and extensive rooting of  plants and for preservation  of natural freshness of fruits, crops and vegetables. Humaur is a non toxic, non pollutant bio-organic foliar spray. Humaur being nutritionally balanced food for plants can be used for all crops.Humaur is easily assimilated in all parts of plant. Humaur favours germinations and rooting of plants Humaur induces sprouting and flowering of plants. Humaur is available in 100 ml., 250 ml., 0.5 ltr, 1 ltr., 5 ltr., 50 ltr. Pack size. Shelf life of Humaur is 60 months.

iv). Azotomeal

Azotomeal is an ecofriendly Nitrogenous liquid bio fertilizer and  is key component of integrated plant nutrient supplement system. It can be used for soil nourishment, seed treatment, and foliar spray. Azotomeal helps in absorption of atmospheric Nitrogen and  supplements fertilizer supplies for meeting the nutrient need. It  nourishes the crop and soil by producing growth regulating substances and vitamins .It also suppresses the incidence of pathogens and control diseases. Azotomeal increases the yield by 20-25%.

Azotomeal is available in 250 ml. and 1 ltr. Bottle and its shelf life is 2 years

v). Phosphomeal

With the increasing demand for higher food production, there is an increase demand for fertilizer supplying Nitrogen and Phosphorous. Phosphorous occupies a critical position both in crop production and in biology of soil. Certain micro-organism are capable of converting the insoluble phosphate to soluble form and making it available to plant.

Phosphomeal contains phosphate solubilising bacteria in the dormant form. In addition to living cells, it is rich in fermentation products such as growth regulators, vitamin and other easily assimilated by plants. It also produces biologically derived chelators that facilitate controlled release of nutrients from soil. Hence it can also used as a foliar spray apart from soil amendment. Phosphomeal soluabilises / immobilises  Phosphorous Pentoxide  and  helps to maintain soil fertility. Phosphomeal provides sustainability to the farming system and is economical, pollution free and based on renewable energy sources

Phosphmeal is available in 250 ml. and 1 ltr. Bottle and its shelf life is 2 years.